Beni, Butembo and Mangina (North Kivu)

An epidemic in North Kivu and Ituri provinces of eastern DRC became the second-largest Ebola outbreak ever, with 3,470 cases and 2,287 deaths (CFR 66%) across nearly two years. Response was complicated by armed-conflict insecurity in the region and required protracted ring vaccination with rVSV-ZEBOV (303,905 doses) plus introduction of monoclonal antibody therapeutics (mAb114 and REGN-EB3) in a randomised trial that established their efficacy. WHO declared the outbreak a Public Health Emergency of International Concern (PHEIC) in July 2019. Three secondary cases were exported to Uganda (Kasese, June 2019) and contained within the country.